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How innovation can help end the AIDS epidemic by 2030

By: Glenda Gray, South African Medical Research Council

File 20181018 67188 12rs5mq.jpg?ixlib=rb 1.1
The WHO recommends HIV viral load testing to monitor people on ARVs.
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A United Nations initiative backed by global experts has set its sights on an ambitious programme to bring an end to the AIDS epidemic by 2030.

The 90-90-90 strategy aims to do this by reaching three targets: 90% of all people with HIV must know their status, 90% of those diagnosed with HIV must receive antiretroviral therapy, and 90% of people receiving antiretroviral therapy must be virally suppressed. When a person is virally suppressed it means the virus in their blood is undetectable. The last goal is informed by evidence that people with a suppressed viral load are less likely to transmit HIV to others.

But a couple of steps still need to be taken before these goals can be met. The first is large scale community based HIV testing that aims to get people tested on an annual basis at the very least. The second is linking testing to care. This is critical because it addresses the gap between a person being diagnosed with HIV to when they start antiretroviral therapy.

The third step is the close monitoring of people taking antiretroviral medication. The World Health Organisation (WHO) recommends viral load testing as the primary method of monitoring people on antiretroviral therapy. Viral load is the measure of the amount of HIV in a person’s blood and is used as a measure of how well a person is responding to HIV treatment. The lower the viral load the better the health outcomes.

WHO guidelines advise that all patients on antiretroviral therapy receive a viral load test at six months and 12 months, and annually thereafter if the patient is stable. But very few patients receive that level of care.

The main barrier is the time it takes to get test results back from laboratories that are often situated great distances from clinics. One way round the problem is to enable viral load testing to take place at primary health care level – what’s known as point-of-care viral load testing. This would be a game changer. Results would be known immediately and health workers could intervene swiftly by evaluating antiretroviral treatments in real time. This would, in turn, improve treatment outcomes.

But achieving this requires innovation. A new approach is being piloted. The idea is to test if point-of-care viral load monitoring is in reach.

Testing

Monitoring the viral loads of people on antiretroviral therapy is an essential part of HIV management. Viral load testing helps doctors determine if a person is taking their medication as prescribed. It also helps to determine if patients are on the correct combination of antiretroviral drugs.

It’s a key part of the arsenal against HIV because research shows that people who are virally suppressed are less likely to pass on the virus to someone else. That makes it a key factor in breaking the cycle of transmission.

The most efficient way of doing this is through point-of-care testing sites. These are based within the community so that patients don’t have to travel long distances to get tests done as well as to receive treatment. This new model is being piloted with the aim of providing convenient access to care for patients.

Currently nearly all viral load testing is conducted in centralised and designated laboratories. This means that there can be lags in getting results back to the field. Patients can wait for weeks.

Laboratory based viral load testing is also expensive. Point-of-care testing is also cheaper than lab-based viral loads: health care workers could do the test rather than highly paid technicians.

Small steps have been made in the direction of enabling viral load monitoring to be done at point of care.

But additional equipment is also needed. Pilots evaluating point-of-care viral load testing are ongoing. A pilot is being run using a portable testing machine – the m-PIMA HIV1/2 – that fits on a desk top and can provide an accurate reading of viral load in under 70 minutes.

The machine is being tested to establish whether it meets WHO standards. Once it is given the stamp of approval by the WHO, ministries of health can start the implementation at all sites.

Closing the gap

All countries still struggling to bring the HIV pandemic under control are focused on achieving the 90-90-90 goals.

South Africa, which still has the biggest HIV epidemic in the world, with 7.9 million people living with HIV, is no exception, and is making significant progress.

It is edging closer to the target of having 90% of people with HIV knowing their status. And it’s made significant progress on the second target that 90% of people with HIV should be on treatment.

But it has some way to go on the third. While the country is on track to meet the goal that 90% of people on treatment be virally suppressed, it’s advances on this front haven’t been uniform. Some regions of the country still lag behind others. Being able to roll out point of care testing would go a long way in helping close these gaps.The Conversation

Glenda Gray, Research Professor, Perinatal HIV Research Unit and President, South African Medical Research Council

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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